Demethylasterriquinone B1
Demethylasterriquinone B1 is a selective insulin receptor activator. Demethylasterriquinone B1 stimulates tyrosine phosphorylation of the IR β subunit, and the activation of PIK3 and AKT[1].
Product Specifications
CAS Number
[78860-34-1]
Product Name Alternative
DAQ B1; L-783281; Dimethylasterriquinone
UNSPSC
12352005
Target
Akt; Insulin Receptor
Type
Natural Products
Related Pathways
PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/demethylasterriquinone-b1.html
Purity
98.10
Solubility
DMF : 15 mg/mL (ultrasonic; warming)
Smiles
C=CC(C)(C1=C(C(C(C(O)=C2C3=CNC4=C3C=CC=C4C/C=C(C)/C)=O)=C(O)C2=O)C5=C(C=CC=C5)N1)C
Molecular Formula
C32H30N2O4
Molecular Weight
506.59
References & Citations
[1]Li M, et al. Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells. Diabetes. 2001;50 (10) :2323-2328.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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