GT-2016

GT-2016 is a potent, selective, and brain penetrant histamine H3 receptor antagonist with a Ki of 43.8 nM. GT-2016 displays selectivity against H1 and H2 receptors, and has non-active against histamine methyltransferase[1].

Product Specifications

CAS Number

[152241-24-2]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gt-2016.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCC(C2=CNC=N2)CC1)CCCCC3CCCCC3

Molecular Formula

C19H31N3O

Molecular Weight

317.47

References & Citations

[1]C E Tedford, et al. Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies. J Pharmacol Exp Ther. 1995 Nov;275 (2) :598-604.