JNJ10191584 (maleate)
JNJ10191584 (VUF6002) maleate (compound 40) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 maleate shows 540-fold selectivity to H4 receptor over the H3 receptor with a Ki value of 14.1 μM. JNJ10191584 maleate inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively[1][2].
Product Specifications
CAS Number
869497-75-6
Product Name Alternative
VUF6002 (maleate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj10191584-maleate.html
Solubility
10 mM in DMSO
Smiles
OC(/C=C\C(O)=O)=O.O=C(N1CCN(CC1)C)C2=NC3=CC(Cl)=CC=C3N2
Molecular Formula
C17H19ClN4O5
Molecular Weight
394.81
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor; H4 Receptor
Frequently Asked Questions
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