VUF 5681 (dihydrobromide)

VUF 5681 dihydrobromide is a neutral antagonist of histamine H3 receptor. VUF 5681 dihydrobromide also has partial agonist function of H3 receptor. VUF 5681 dihydrobromide blocks the effects of Thioperamide (HY-12206) . VUF 5681 dihydrobromide is used in central nervous system disease research[1][2].

Product Specifications

CAS Number

[639089-06-8]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vuf-5681-dihydrobromide.html

Solubility

10 mM in DMSO

Smiles

C1(CCCC2CCNCC2)=CN=CN1.Br.Br

Molecular Formula

C11H21Br2N3

Molecular Weight

355.11

References & Citations

[1]Moreno-Delgado D, et al. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51 (3) :517-23.|[2]Baker JG. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacol. 2008 Jun 6;8:9.