VUF 5681 (dihydrobromide)
VUF 5681 dihydrobromide is a neutral antagonist of histamine H3 receptor. VUF 5681 dihydrobromide also has partial agonist function of H3 receptor. VUF 5681 dihydrobromide blocks the effects of Thioperamide. VUF 5681 dihydrobromide is used in central nervous system disease research[1][2].
Product Specifications
CAS Number
639089-06-8
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vuf-5681-dihydrobromide.html
Solubility
10 mM in DMSO
Smiles
C1(CCCC2CCNCC2)=CN=CN1.Br.Br
Molecular Formula
C11H21Br2N3
Molecular Weight
355.11
References & Citations
[1]Moreno-Delgado D, et al. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51 (3) :517-23.|[2]Baker JG. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacol. 2008 Jun 6;8:9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor
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