Chetomin
Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC) -targeting molecule[1].
Product Specifications
CAS Number
1403-36-7
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chetomin.html
Purity
99.0
Solubility
DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
O=C1N2[C@]3([H])[C@](C4=CC=CC=C4N3)(N5C6=CC=CC=C6C(C[C@@]7(N8C)C(N([C@](SS7)(CO)C8=O)C)=O)=C5)C[C@]29C(N(C)[C@]1(SS9)CO)=O
Molecular Formula
C31H30N6O6S4
Molecular Weight
710.87
Precautions
H301
References & Citations
[1]Min S, et al. Chetomin, a Hsp90/HIF1α pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells. Cancer Biol Ther. 2020;21 (8) :698-708.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
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