Chetomin

Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC) -targeting molecule[1].

Product Specifications

CAS Number

[1403-36-7]

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; HSP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/chetomin.html

Purity

99.0

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

O=C1N2[C@]3([H])[C@](C4=CC=CC=C4N3)(N5C6=CC=CC=C6C(C[C@@]7(N8C)C(N([C@](SS7)(CO)C8=O)C)=O)=C5)C[C@]29C(N(C)[C@]1(SS9)CO)=O

Molecular Formula

C31H30N6O6S4

Molecular Weight

710.87

Precautions

H301

References & Citations

[1]Min S, et al. Chetomin, a Hsp90/HIF1α pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells. Cancer Biol Ther. 2020;21 (8) :698-708.