8-pCPT-2'-O-Me-cAMP-AM

8-pCPT-2'-O-Me-cAMP-AM is a cyclic AMP analogue, selectively activates Epac-Rap signaling pathway. 8-pCPT-2'-O-Me-cAMP-AM protects renal function by activating Epac from ischemia injury. 8-pCPT-2'-O-Me-cAMP-AM also stimulates insulin secretion by interaction with PKA pathway[1][2].

Product Specifications

CAS Number

[1152197-23-3]

UNSPSC

12352005

Target

PKA

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/8-pcpt-2-o-me-camp-am.html

Purity

99.0

Solubility

DMSO : 55.79 mg/mL (ultrasonic)

Smiles

NC1=C2C(N([C@@]3([H])[C@@H]([C@@]4([H])[C@](COP(OCOC(C)=O)(O4)=O)([H])O3)OC)C(SC5=CC=C(C=C5)Cl)=N2)=NC=N1

Molecular Formula

C20H21ClN5O8PS

Molecular Weight

557.90

References & Citations

[1]Stokman G, et al. Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure. J Am Soc Nephrol. 2011 May;22 (5) :859-72. |[2]Chepurny OG, et al. Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM. J Biol Chem. 2009 Apr 17;284 (16) :10728-36.