T-98475
T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM[1].
Product Specifications
CAS Number
199119-18-1
UNSPSC
12352005
Target
GnRH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/t-98475.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(CC2=C(F)C=CC=C2F)C3=C(C1=O)C(CN(CC4=CC=CC=C4)C)=C(C5=CC=C(NC(C(C)C)=O)C=C5)S3)OC(C)C
Molecular Formula
C37H37F2N3O4S
Molecular Weight
657.77
References & Citations
[1]Imada T, et al. Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists. J Med Chem. 2006 Jun 29;49 (13) :3809-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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