TC-G 24
TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases[1].
Product Specifications
CAS Number
1257256-44-2
UNSPSC
12352005
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tc-g-24.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CC=C(C2=NN=C(NC3=CC=C(C)C(Cl)=C3)O2)C=C1)[O-]
Molecular Formula
C15H11ClN4O3
Molecular Weight
330.73
References & Citations
[1]Khanfar MA, et al. Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J Med Chem. 2010 Dec 23;53 (24) :8534-45.|[2]Lihui Wang, et al. FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping. Cell Metab. 2020 Nov 3;32 (5) :860-877.e9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
Frequently Asked Questions
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