Org 25543 (hydrochloride)

Org 25543 hydrochloride is a selective and irreversible GlyT2 inhibitor (IC50: 16 nM) . Org 25543 hydrochloride has analgesia effect. Org 25543 hydrochloride ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice[1][2][3].

Product Specifications

CAS Number

[495076-64-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/org-25543-hydrochloride.html

Purity

99.93

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC(C=C(C(NCC1(CCCC1)N(C)C)=O)C=C2OC)=C2OCC3=CC=CC=C3.[H]Cl

Molecular Formula

C24H33ClN2O4

Molecular Weight

448.98

Precautions

H315, H319, H335

References & Citations

[1]Caulfield WL, et al. The first potent and selective inhibitors of the glycine transporter type 2. J Med Chem. 2001 Aug 16;44 (17) :2679-82.|[2]Morita K, et al. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J Pharmacol Exp Ther. 2008 Aug;326 (2) :633-45.|[3]Mohammadzadeh A, et al. Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model. Int J Mol Sci. 2021 Mar 1;22 (5) :2479.