(Rac)-ALX 5407
Product Specifications
UNSPSC Description
NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively[1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion[2].
Target Antigen
GlyT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rac-alx-5407.html
Solubility
10 mM in DMSO
Smiles
OC(CN(C)CCC(C1=CC=C(F)C=C1)OC2=CC=C(C3=CC=CC=C3)C=C2)=O
Molecular Weight
393.45
References & Citations
[1]Mallorga PJ, et al. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology. 2003 Oct;45(5):585-93.|[2]Huang B, et al. GlyT1 Inhibitor NFPS Exerts Neuroprotection via GlyR Alpha1 Subunit in the Rat Model of Transient Focal Cerebral Ischaemia and Reperfusion. Cell Physiol Biochem. 2016;38(5):1952-62.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107526/Rac-ALX-5407-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107526/
Clinical Information
No Development Reported
CAS Number
405225-21-0
Curated Selection
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