(Rac) -ALX 5407

NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively[1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion[2].

Product Specifications

CAS Number

[405225-21-0]

Product Name Alternative

(Rac) -NFPS

UNSPSC

12352005

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rac-alx-5407.html

Solubility

10 mM in DMSO

Smiles

OC(CN(C)CCC(C1=CC=C(F)C=C1)OC2=CC=C(C3=CC=CC=C3)C=C2)=O

Molecular Formula

C24H24FNO3

Molecular Weight

393.45

References & Citations

[1]Mallorga PJ, et al. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]- (N-[3- (4'-fluorophenyl) -3- (4'phenylphenoxy) propyl]) sarcosine. Neuropharmacology. 2003 Oct;45 (5) :585-93.|[2]Huang B, et al. GlyT1 Inhibitor NFPS Exerts Neuroprotection via GlyR Alpha1 Subunit in the Rat Model of Transient Focal Cerebral Ischaemia and Reperfusion. Cell Physiol Biochem. 2016;38 (5) :1952-62.