(±) -HIP-A

(±) -HIP-A is a non-competitive excitatory amino acid transporter (EAAT) blocker that effectively blocks Glu uptake (IC50=17-18 μM) . (±) -HIP-A is also a lead compound against ischemia-induced neuronal degeneration. (±) -HIP-A can be used in the study of neurological diseases[1].

Product Specifications

CAS Number

[227619-64-9]

UNSPSC

12352005

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/racemic-hip-a.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H]1[C@]2([H])[C@](ONC2=O)([H])CN1)=O

Molecular Formula

C6H8N2O4

Molecular Weight

172.14

References & Citations

[1]Andrea Pinto, et al. Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters.