(RS) -PPG

(RS) -PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].

Product Specifications

CAS Number

[120667-15-4]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rs-ppg.html

Purity

99.76

Solubility

H2O : 2.86 mg/mL (ultrasonic; warming; adjust pH to 12 with 0.5 M NaOH; heat to 60°C)

Smiles

O=C(O)C(N)C1=CC=C(P(O)(O)=O)C=C1

Molecular Formula

C8H10NO5P

Molecular Weight

231.14

References & Citations

[1]Gasparini F, et al. (R, S) -4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J Pharmacol Exp Ther. 1999 Jun;289 (3) :1678-87.|[2]Zhao L, et al. Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons. Neurotox Res. 2009 Aug;16 (2) :174-83.