Ro 67-4853
Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor) . Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation[1][2][3][4].
Product Specifications
CAS Number
302841-89-0
UNSPSC
12352005
Hazard Statement
H302, H361, H372, H410
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro-67-4853.html
Purity
99.90
Solubility
DMF : 16 mg/mL (ultrasonic; warming)
Smiles
CCCCOC(NC(C1C2=CC=CC=C2OC3=CC=CC=C13)=O)=O
Molecular Formula
C19H19NO4
Molecular Weight
325.36
Precautions
H302, H361, H372, H410
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1
Frequently Asked Questions
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