VU0360172 (hydrochloride)

VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].

Product Specifications

CAS Number

[1309976-62-2]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0360172-hydrochloride.html

Purity

98.94

Solubility

10 mM in DMSO

Smiles

O=C(C1=CN=C(C=C1)C#CC2=CC(F)=CC=C2)NC3CCC3.Cl

Molecular Formula

C18H16ClFN2O

Molecular Weight

330.78

References & Citations

[1]Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78 (6) :1105-23.