MMPIP

MMPIP is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM) . MMPIP acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP alleviates pain and normalizes affective and cognitive behavior in neuropathic mice[1][2].

Product Specifications

CAS Number

[479077-02-6]

UNSPSC

12352005

Hazard Statement

H301

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mmpip.html

Purity

99.38

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(ON=C2C3=CC=NC=C3)C=C(C4=CC=C(OC)C=C4)N1C

Molecular Formula

C19H15N3O3

Molecular Weight

333.34

Precautions

H301

References & Citations

[1]Gentaroh Suzuki, et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J Pharmacol Exp Ther. 2007 Oct;323 (1) :147-56.|[2]Paulina Cieślik, et al. Negative Allosteric Modulators of mGlu 7 Receptor as Putative Antipsychotic Drugs. Front Mol Neurosci. 2018 Sep 20;11:316.