Amtolmetin guacil

Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX) . Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO) . Amtolmetin guacil can be used to research knee osteoarthritis[1][2].

Product Specifications

CAS Number

[87344-06-7]

UNSPSC

12352005

Hazard Statement

H301

Target

COX; NO Synthase; Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/amtolmetin-guacil.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C)C=C1)C2=CC=C(CC(NCC(OC3=C(C=CC=C3)OC)=O)=O)N2C

Molecular Formula

C24H24N2O5

Molecular Weight

420.46

Precautions

H301

References & Citations

[1]Marcolongo, R., et al. A Meta-Analysis of the Tolerability of Amtolmetin Guacil, a Novel, Effective Nonsteroidal Anti-Inflammatory Drug, Compared with Established Agents. Clin. Drug Investig. 17, 89-96 (1999) .|[2]Niccoli L, et al. Renal tolerability of three commonly employed non-steroidal anti-inflammatory drugs in elderly patients with osteoarthritis. Clin Exp Rheumatol. 2002 Mar-Apr;20 (2) :201-7.|[3]Hotha KK, et al. Species difference in the in vitro and in vivo metabolism of amtolmetin guacil. Arzneimittelforschung. 2010;60 (11) :667-74.