RKI-1313
RKI-1313 is a ROCK inhibitor with IC50s of 34, 8 µM for ROCK 1 and ROCK 2, respectively. RKI-1313 shows little effect on the phosphorylation levels of ROCK substrates, migration, invasion or anchorage-independent growth[1].
Product Specifications
CAS Number
[1342276-76-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rki-1313.html
Purity
98.2
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
COC1=CC=CC(CNC(NC2=NC(C3=CC=NC=C3)=CS2)=O)=C1
Molecular Formula
C17H16N4O2S
Molecular Weight
340.40
Precautions
H302, H315, H320, H335
References & Citations
[1]Patel RA, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72 (19) :5025-34.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK1; ROCK2
Curated Selection
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