Propentofylline

Propentofylline is a xanthine-derivative that inhibits adenosine uptake and blocks phosphodiesterase activity. Propentofylline has neuroprotective, antiproliferative, and anti-inflammatory effects that improve cognition and dementia severity in patients with Alzheimer's disease or vascular dementia.

Product Specifications

CAS Number

[55242-55-2]

Product Name Alternative

HWA 285

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/propentofylline.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N(C)C(N1CCCCC(C)=O)=O)N=CN2CCC

Molecular Formula

C15H22N4O3

Molecular Weight

306.36

Precautions

H302+H312+H332

References & Citations

[1]Hudlicka O, Komarek J, Wright AJ. The effect of a xanthine derivative, 1- (5' oxohexyl) -3-methyl-7-propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits. Br J Pharmacol. 1981;72 (4) :723-730. |[2]Sweitzer S, De Leo J. Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. Handb Exp Pharmacol. 2011; (200) :235-250.