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Simmitecan (hydrochloride)

Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2].

Product Specifications

CAS Number

1247847-78-4

UNSPSC

12352005

Target

Cytochrome P450; Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/simmitecan-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.CC[C@]1(O)C(C=C2N3CC4=CC5=C(C=CC(OC(N6CCC(N7CCCCC7)CC6)=O)=C5CC=C)N=C42)=C(COC1=O)C3=O

Molecular Formula

C34H39ClN4O6

Molecular Weight

635.15

References & Citations

[1]Rini B, et al. A phase I/II study of lenalidomide in combination with sunitinib in patients with advanced or metastatic renal cell carcinoma. Ann Oncol. 2014 Sep;25 (9) :1794-1799. |[2]Hu ZY, et al. Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals. Acta Pharmacol Sin. 2013 Nov;34 (11) :1437-48.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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