RTI 336
RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels[1].
Product Specifications
CAS Number
204069-50-1
UNSPSC
12352005
Target
Dopamine Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rti-336.html
Solubility
10 mM in DMSO
Smiles
CN1[C@H]2[C@@H](C3=CC(C4=CC=C(C)C=C4)=NO3)[C@@H](C5=CC=C(Cl)C=C5)C[C@@H]1CC2.Cl
Molecular Formula
C24H26Cl2N2O
Molecular Weight
429.38
References & Citations
[1]Haile CN, et al. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain Res. 2005 Sep 7;1055 (1-2) :186-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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