7β-Hydroxy-epi-androsterone
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone[1][2][3].
Product Specifications
CAS Number
25848-69-5
Product Name Alternative
7β-Hydroxy-EpiA
UNSPSC
12352211
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/7β-hydroxy-epi-androsterone.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@]3([H])[C@]([C@@H](O)C[C@@]1([H])C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3
Molecular Formula
C19H30O3
Molecular Weight
306.44
References & Citations
[1]Christophe Ricco, et al. Synthesis of 7β-hydroxy-epiandrosterone. Steroids. Volume 76, Issues 1-2, January 2011, Pages 28-30. |[2]Sandra N, et al. The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. Steroids. 2012 Apr;77 (5) :542-51.|[3]Hennebert O, et al. Anti-inflammatory effects and changes in prostaglandin patterns induced by 7beta-hydroxy-epiandrosterone in rats with colitis. J Steroid Biochem Mol Biol. 2008 Jun;110 (3-5) :255-62. |[4]Dudas B, et al. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol Dis. 2004 Mar;15 (2) :262-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ERβ
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