Nebentan
Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan. Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].
Product Specifications
CAS Number
403604-85-3
Product Name Alternative
YM598 (free base)
UNSPSC
12352005
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/nebentan-free-base.html
Purity
99.67
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(/C=C/C1=CC=CC=C1)(NC2=NC(C3=NC=CC=N3)=NC(OC)=C2OC4=CC=CC=C4OC)=O
Molecular Formula
C24H21N5O5S
Molecular Weight
491.52
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ETA; ETB
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
![Mouse Monoclonal CD2 Antibody (B-E2) [DyLight 488]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
Mouse Monoclonal CD2 Antibody (B-E2) [DyLight 488]
Horse NF-Kappa-B Essential Modulator (IKBKG) ELISA Kit