ZD-9379

ZD-9379 is a potent, orally active, and brain penetrant full antagonist at the glycine site of the NMDA receptor. ZD-9379 has neuroprotective effect[1][2].

Product Specifications

CAS Number

170142-20-8

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zd-9379.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C(NN1C3=C(C=C(OC)C=C3)C)=O)NC4=C(C=CC(Cl)=C4)C2=O

Molecular Formula

C19H14ClN3O4

Molecular Weight

383.79

References & Citations

[1]Tatlisumak T, et al. A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Stroke. 1998;29 (1) :190-195.|[2]ZD 9379. Drugs R D. 1999;1 (1) :44-45.