MK 386
MK 386 (L-733692) is a selective 5-α-reductase I inhibitor, used for prostate cancer inhibition[1].
Product Specifications
CAS Number
158493-17-5
Product Name Alternative
L-733692
UNSPSC
12352005
Target
5 alpha Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mk-386.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@]3([H])[C@]([C@@H](C)C[C@@]1([H])N(C(CC2)=O)C)([H])[C@@]4([H])[C@@](C)([C@]([C@H](C)CCCC(C)C)([H])CC4)CC3
Molecular Formula
C28H49NO
Molecular Weight
415.69
References & Citations
[1]Bühler P, et al. Comparison of gene expression in LNCaP prostate cancer cells after treatment with bicalutamide or 5-alpha-reductase inhibitors. Urol Int. 2010;84 (2) :203-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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