Trimegestone
Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR) . Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity) . Trimegestone can be used in studies of contraception or menopausal syndromes[1][2].
Product Specifications
CAS Number
74513-62-5
Product Name Alternative
RU 27987
UNSPSC
12352211
Hazard Statement
H319
Target
Androgen Receptor; Phosphatase; Progesterone Receptor
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/trimegestone.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC[C@]2(C)C([C@@H](O)C)=O)([H])[C@@]3([H])C(CC1)=C4C(CC3)=CC(CC4)=O
Molecular Formula
C22H30O3
Molecular Weight
342.47
Precautions
P264-P280-P305+P351+P338
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
Frequently Asked Questions
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