Tebufelone

Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].

Product Specifications

CAS Number

[112018-00-5]

Product Name Alternative

NE-11740

UNSPSC

12352005

Target

COX; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tebufelone.html

Purity

99.52

Solubility

10 mM in DMSO

Smiles

OC1=C(C=C(C(CCCC#C)=O)C=C1C(C)(C)C)C(C)(C)C

Molecular Formula

C20H28O2

Molecular Weight

300.44

References & Citations

[1]S M Weisman, et al. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41 (3-4) :156-63. |[2]Sebastian Braun, et al. Carborane-Based Tebufelone Analogs and Their Biological Evaluation In Vitro. ChemMedChem. 2023 Jul 17;18 (14) :e202300206.