Tebufelone
Product Specifications
UNSPSC Description
Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].
Target Antigen
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tebufelone.html
Purity
99.52
Solubility
10 mM in DMSO
Smiles
OC1=C(C=C(C(CCCC#C)=O)C=C1C(C)(C)C)C(C)(C)C
Molecular Weight
300.44
References & Citations
[1]S M Weisman, et al. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41(3-4):156-63. |[2]Sebastian Braun, et al. Carborane-Based Tebufelone Analogs and Their Biological Evaluation In Vitro. ChemMedChem. 2023 Jul 17;18(14):e202300206.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-106823/Tebufelone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-106823/Tebufelone-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
112018-00-5
Curated Selection
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