Ceronapril
Ceronapril (SQ 29852) is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with an IC50 of 36 nM[1].
Product Specifications
CAS Number
111223-26-8
Product Name Alternative
Ceranapril; SQ 29852
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ceronapril.html
Solubility
10 mM in DMSO
Smiles
O=P(CCCCC1=CC=CC=C1)(O)O[C@@H](CCCCN)C(N2[C@@H](CCC2)C(O)=O)=O
Molecular Formula
C21H33N2O6P
Molecular Weight
440.47
References & Citations
[1]Karanewsky D S, et al. (Phosphinyloxy) acyl amino acid inhibitors of angiotensin converting enzyme (ACE) . 1. Discovery of (S) -1-[6-amino-2-[[hydroxy (4-phenylbutyl) phosphinyl] oxy]-1-oxohexyl]-L-proline, a novel orally active inhibitor of ACE. Journal of medicinal chemistry, 1988, 31 (1) : 204-212.|[2]Chen BZ, et al. Effect of acute and chronic administration of ceronapril on angiotensin converting enzyme in plasma, kidney, lung, brain regions and cerebrospinal fluid of rats. Neuropharmacology. 1992 Sep;31 (9) :929-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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