Ceronapril

Ceronapril (SQ 29852) is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with an IC50 of 36 nM[1].

Product Specifications

CAS Number

[111223-26-8]

Product Name Alternative

Ceranapril; SQ 29852

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ceronapril.html

Solubility

10 mM in DMSO

Smiles

O=P(CCCCC1=CC=CC=C1)(O)O[C@@H](CCCCN)C(N2[C@@H](CCC2)C(O)=O)=O

Molecular Formula

C21H33N2O6P

Molecular Weight

440.47

References & Citations

[1]Karanewsky D S, et al. (Phosphinyloxy) acyl amino acid inhibitors of angiotensin converting enzyme (ACE) . 1. Discovery of (S) -1-[6-amino-2-[[hydroxy (4-phenylbutyl) phosphinyl] oxy]-1-oxohexyl]-L-proline, a novel orally active inhibitor of ACE. Journal of medicinal chemistry, 1988, 31 (1) : 204-212.|[2]Chen BZ, et al. Effect of acute and chronic administration of ceronapril on angiotensin converting enzyme in plasma, kidney, lung, brain regions and cerebrospinal fluid of rats. Neuropharmacology. 1992 Sep;31 (9) :929-35.