Plaunotol
Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer [1]. Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer [2].
Product Specifications
CAS Number
64218-02-6
Product Name Alternative
CS-684
UNSPSC
12352211
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/plaunotol.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C\CC/C(C)=C/CC/C(CO)=C/CC/C(C)=C/CO
Molecular Formula
C20H34O2
Molecular Weight
306.48
References & Citations
[1]S. Songkro, et al. Investigation of plaunoi-loaded micro/nanoemulsions for the treatment of dermatitis: formulation, evaluation and skin irritation studies. J. DRUG DEL. SCI. TECH. 2011 21 (5) 401-410.|[2]Oshikawa N, et al. Plaunotol and geranylgeraniol induce caspase-mediated apoptosis in colon cancer. J Surg Res. 2009 May 15;153 (2) :246-53.|[3]Ohta Y, et al. Plaunotol prevents the progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats. Pharmacology. 2005 Jul;74 (4) :182-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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