Amosulalol

Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR) [1].

Product Specifications

CAS Number

[85320-68-9]

Product Name Alternative

YM 09538

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/amosulalol.html

Purity

98.69

Solubility

10 mM in DMSO

Smiles

NS(=O)(C1=CC(C(O)CNCCOC2=C(C=CC=C2)OC)=CC=C1C)=O

Molecular Formula

C18H24N2O5S

Molecular Weight

380.46

References & Citations

[1]Honda K, et al. Autonomic and antihypertensive activity of oral amosulalol (YM-09538), a combined alpha- and beta-adrenoceptor blocking agent in conscious rats. Jpn J Pharmacol. 1985 May;38 (1) :31-41.