Dihydro-5-azacytidine (acetate)
Product Specifications
UNSPSC Description
Dihydro-5-azacytidine acetate (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine acetate has an antitumor activity[1][2].
Target Antigen
DNA Methyltransferase; Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dihydro-5-azacytidine-acetate.html
Solubility
10 mM in DMSO
Smiles
NC(NC1)=NC(N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=O.CC(O)=O
Molecular Weight
306.27
References & Citations
[1]Robert A Kratzke, et al. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. J Thorac Oncol. 2008 Apr;3(4):417-21.|[2]W C Powell, et al. Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210)-bearing mice. Cancer Chemother Pharmacol. 1988;21(2):117-21.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-106689A/Dihydro-5-azacytidine-acetate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-106689A/
Clinical Information
No Development Reported
CAS Number
2470972-18-8
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