Dihydro-5-azacytidine (acetate)

Dihydro-5-azacytidine acetate (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine acetate has an antitumor activity[1][2].

Product Specifications

CAS Number

[2470972-18-8]

Product Name Alternative

DHAC (acetate) ; NSC 264880 (acetate)

UNSPSC

12352005

Target

DNA Methyltransferase; Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dihydro-5-azacytidine-acetate.html

Solubility

10 mM in DMSO

Smiles

NC(NC1)=NC(N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=O.CC(O)=O

Molecular Formula

C10H18N4O7

Molecular Weight

306.27

References & Citations

[1]Robert A Kratzke, et al. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. J Thorac Oncol. 2008 Apr;3 (4) :417-21.|[2]W C Powell, et al. Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210) -bearing mice. Cancer Chemother Pharmacol. 1988;21 (2) :117-21.