Dihydro-5-azacytidine
Dihydro-5-azacytidine (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine has an antitumor activity[1][2].
Product Specifications
CAS Number
62488-57-7
Product Name Alternative
DHAC; NSC 264880
UNSPSC
12352005
Target
DNA Methyltransferase; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dihydro-5-azacytidine.html
Solubility
10 mM in DMSO
Smiles
NC(NC1)=NC(N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=O
Molecular Formula
C8H14N4O5
Molecular Weight
246.22
References & Citations
[1]Robert A Kratzke, et al. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. J Thorac Oncol. 2008 Apr;3 (4) :417-21.|[2]W C Powell, et al. Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210) -bearing mice. Cancer Chemother Pharmacol. 1988;21 (2) :117-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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