Quinupramine
Quinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system[1][2].
Product Specifications
CAS Number
31721-17-2
Product Name Alternative
LM 208
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/quinupramine.html
Solubility
10 mM in DMSO
Smiles
N1(C2C3CCN(CC3)C2)C4=CC=CC=C4CCC5=C1C=CC=C5
Molecular Formula
C21H24N2
Molecular Weight
304.43
References & Citations
[1]Sakamoto H, et al. Effects of quinupramine on the central monoamine uptake systems and involvement of pharmacokinetics in its pharmacological activities. Jpn J Pharmacol. 1987;45 (2) :169-175.|[2]Sakamoto H, et al. Down-regulation of central serotonin S2 receptors after repeated treatment with quinupramine in rats. Jpn J Pharmacol. 1987;43 (4) :369-377.|[3]Shin SC, et al. Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats. Pharm Dev Technol. 2007;12 (5) :429-436.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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