Pildralazine

Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].

Product Specifications

CAS Number

[64000-73-3]

Product Name Alternative

Propyldazine

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pildralazine.html

Solubility

10 mM in DMSO

Smiles

CC(O)CN(C(C=C/1)=NNC1=N\N)C

Molecular Formula

C8H15N5O

Molecular Weight

197.24

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Della Porta G, Dragani TA. Carcinogenicity study in mice on pildralazine, a hydralazinelike antihypertensive compound. J Cancer Res Clin Oncol. 1983;106 (2) :97-101. |[2]Chevillard C, et al. Interactions between hydralazine, propildazine and purines on arterial smooth muscle. Br J Pharmacol. 1981 Aug;73 (4) :811-7. |[3]Dorigotti L, et al. Effects of pildralazine alone and in combination on severe hypertension and cerebrovascular lesions in saline-drinking spontaneously hypertensive rats. Arzneimittelforschung. 1984;34 (8) :876-9.