L-Buthionine- (S, R) -sulfoximine (hydrochloride)
L-Buthionine- (S, R) -sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine- (S, R) -sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively[1][2].
Product Specifications
Product Name Alternative
L-Buthionine sulfoximine (hydrochloride) ; L-BSO (hydrochloride)
UNSPSC
12352211
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/l-buthionine-s-r-sulfoximine-hydrochloride.html
Purity
98.39
Solubility
H2O : 70 mg/mL (ultrasonic)
Smiles
N[C@H](C(O)=O)CCS(CCCC)(=O)=N.[H]Cl
Molecular Formula
C8H19ClN2O3S
Molecular Weight
258.77
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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