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Peplomycin

Peplomycin (Bleomycin PEP) is an analog of Bleomycin and an antitumor antibiotic. Peplomycin exhibits potent antitumor activity and relatively low pulmonary toxicity. Peplomycin can induce various skin abnormalities and trigger apoptosis in SSCKN cells of oral squamous cell carcinoma. Peplomycin can also induce pulmonary fibrosis. Peplomycin is applicable for the research of tumors, pulmonary fibrosis and other related diseases[1][2][3][4].

Product Specifications

CAS Number

68247-85-8

Product Name Alternative

Bleomycin PEP; Pepleomycin

UNSPSC

12352005

Target

Antibiotic; Apoptosis

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/peplomycin.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@@](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCN[C@H](C4=CC=CC=C4)C)=O)=CS3)=CS2)=O)=O)=O)([H])[C@H](C5=CNC=N5)O[C@H]6[C@H]([C@H]([C@H](O)[C@H](CO)O6)O)O[C@]7([H])[C@H]([C@H]([C@H](O)[C@@H](CO)O7)OC(N)=O)O

Molecular Formula

C61H88N18O21S2

Molecular Weight

1473.59

References & Citations

[1]Carter SK, et al. Peplomycin. Cancer Treat Rev. 1984 Dec;11 (4) :303-5. |[2]Asano Y, et al. A case of peplomycin-induced scleroderma. Br J Dermatol. 2004 Jun;150 (6) :1213-4. |[3]Okamura H, et al. Peplomycin-induced apoptosis in oral squamous carcinoma cells depends on bleomycin sensitivity. Oral Oncol. 2001 Jun;37 (4) :379-85. |[4]Osaki T, et al. Peplomycin, a bleomycin derivative, induces myofibroblasts in pulmonary fibrosis. Int J Exp Pathol. 2001 Aug;82 (4) :231-41.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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