ILS-920
ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC) . ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12[1].
Product Specifications
CAS Number
892494-07-4
UNSPSC
12352005
Target
Calcium Channel; FKBP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ils-920.html
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C57H86N2O14
Molecular Weight
1023.30
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
FKBP52; L-type calcium channel
Frequently Asked Questions
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