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Flurocitabine

Flurocitabine (5-Fluorocyclocytidine) is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU) ) . Flurocitabine (5-Fluorocyclocytidine) has antitumor activity during phase I studies in acute leukemia and solid tumors[1].

Product Specifications

CAS Number

37717-21-8

Product Name Alternative

5-Fluorocyclocytidine; 5'-Fluorocyclocytidine

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/flurocitabine.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@]2([H])[C@](O[C@@H]1CO)([H])N3C(O2)=NC(C(F)=C3)=N

Molecular Formula

C9H10FN3O4

Molecular Weight

243.19

References & Citations

[1]Alberto P, et al. Phase II study of anhydro-ara-5-fluorocytidine in adenocarcinoma of gastrointestinal tract, epidermoid carcinoma of lung, head and neck, breast carcinoma and small cell anaplastic carcinoma of lung. A study report of the E.O.R.T.C. early clinical trial cooperative group. Eur J Cancer. 1978;14 (2) :195-201.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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