Rucaparib (hydrochloride)
Rucaparib (AG014699) hydrochloride is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib hydrochloride is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib hydrochloride has the potential for castration-resistant prostate cancer (CRPC) research[1][2][3][4].
Product Specifications
CAS Number
773059-19-1
Product Name Alternative
AG014699 (hydrochloride) ; PF-01367338 (hydrochloride)
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rucaparib-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
FC1=CC2=C3C(CCNC2=O)=C(C4=CC=C(CNC)C=C4)NC3=C1.[H]Cl
Molecular Formula
C19H19ClFN3O
Molecular Weight
359.83
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PARP1; PARP2; PARP3
Frequently Asked Questions
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