T-1095
T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 μM and 2.3 μM for human SGLT1 and SGLT2, respectively. T-1095 can be used for diabetes research[1].
Product Specifications
CAS Number
209746-59-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/t-1095.html
Purity
99.40
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C(C(O)=C1)=C(C=C1C)O[C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@H]2O)COC(OC)=O)CCC3=CC=C4C(C=CO4)=C3
Molecular Formula
C26H28O11
Molecular Weight
516.49
Precautions
H302, H315, H319
References & Citations
[1]A Oku, et al. T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes. 1999 Sep;48 (9) :1794-800.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
SGLT1; SGLT2
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