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Eniporide

Eniporide (EMD 96785) is a Na (+) /H (+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest[1][2].

Product Specifications

CAS Number

176644-21-6

Product Name Alternative

EMD-96785

UNSPSC

12352200

Hazard Statement

H302-H315-H319-H332-H335

Target

Na+/H+ Exchanger (NHE)

Type

Biochemical Assay Reagents

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/eniporide.html

Solubility

10 mM in DMSO

Smiles

CS(=O)(C1=C(N2C=CC=C2)C=C(C)C(C(NC(N)=N)=O)=C1)=O

Molecular Formula

C14H16N4O3S

Molecular Weight

320.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Zeymer U, et al. The Na (+) /H (+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol. 2001 Nov 15;38 (6) :1644-50. |[2]Klass O, et al. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. Ann Thorac Surg. 2004 Feb;77 (2) :658-63.

Shipping Conditions

Room temperature

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Frequently Asked Questions

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