Echinomycin
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2].
Product Specifications
CAS Number
512-64-1
Product Name Alternative
Quinomycin A; NSC-13502
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H361
Target
Antibiotic; Bacterial; HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/echinomycin.html
Purity
98.57
Solubility
DMSO : 5.3 mg/mL (ultrasonic)
Smiles
[H]C1=NC2=C(N=C1C(N[C@H](COC([C@H](C(C)C)N(C)C([C@H]3N4C)=O)=O)C(N[C@@H](C)C(N(C)[C@@H]([C@@H](SC)SC3)C(N(C)[C@@H](C(C)C)C(OC[C@@H](NC(C5=NC6=C(C=CC=C6)N=C5[H])=O)C(N[C@@H](C)C4=O)=O)=O)=O)=O)=O)=O)C=CC=C2
Molecular Formula
C51H64N12O12S2
Molecular Weight
1101.26
Precautions
H301, H311, H331, H361
References & Citations
[1]Kong D, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 Oct 1;65 (19) :9047-55.|[2]Wang Y, et al. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011 Apr 8;8 (4) :399-411.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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