Nocloprost

Nocloprost, a prostaglandin E2 (PGE2) analog, is an orally active EP1- and EP3-receptor agonist. Nocloprost inhibits evoked [3H]ACh release. Nocloprost has gastroprotective and ulcer-healing properties. Nocloprost accelerates the healing of chronic gastric ulcerations and enhances mucosal growth in rats[1][2].

Product Specifications

CAS Number

[79360-43-3]

UNSPSC

12352211

Hazard Statement

H225, H319, H336, H360

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nocloprost.html

Solubility

10 mM in DMSO

Smiles

CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H]([C@H](Cl)C[C@H]1O)C/C=C\CCCC(O)=O

Molecular Formula

C22H37ClO4

Molecular Weight

400.98

Precautions

H225, H319, H336, H360

References & Citations

[1]S J Konturek, et al. Nocloprost, a unique prostaglandin E2 analog with local gastroprotective and ulcer-healing activity. Eur J Pharmacol. 1991 Apr 3;195 (3) :347-57.|[2]T Reinheimer, et al. Prostanoid receptors of the EP3 subtype mediate inhibition of evoked [3H]acetylcholine release from isolated human bronchi. Br J Pharmacol. 1998 Sep;125 (2) :271-6.