4α-TPA
4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events[1].
Product Specifications
CAS Number
63597-44-4
Product Name Alternative
α-TPA
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
NF-κB; PKC; SphK
Type
Reference compound
Related Pathways
Epigenetics; Immunology/Inflammation; NF-κB; TGF-beta/Smad
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4α-tpa.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(CCCCCCCCCCCCC)=O)C)([C@@]4([H])[C@@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O
Molecular Formula
C36H56O8
Molecular Weight
616.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Chiu WT, et al. Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE (2) activation. Neurobiol Dis. 2010;37 (1) :118-129.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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