Ketotrexate (sodium)

Ketotrexate sodium is an orally active antifolate and immunosuppressant. Ketotrexate sodium has good anti-inflammatory activity and is widely used in rheumatoid arthritis (RA) . Ketotrexate sodium is used in research into cancer and autoimmune diseases[1][2].

Product Specifications

CAS Number

[52386-42-2]

Product Name Alternative

Emofolin (sodium) ; 5-methyltetrahydrohomofolate (sodium) ; NSC 139490 (sodium)

UNSPSC

12352005

Target

Antifolate

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ketotrexate-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C(CC[C@H](NC(C1=CC=C(C=C1)NCCC2N(C3=C(NC2)NC(N)=NC3=O)C)=O)C(O[Na])=O)O[Na]

Molecular Formula

C21H25N7Na2O6

Molecular Weight

517.45

References & Citations

[1]Puig L. Methotrexate: new therapeutic approaches. Actas Dermosifiliogr. 2014 Jul-Aug;105 (6) :583-9. |[2]Torres RP, et al. Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis. ARP Rheumatol. 2022 Oct 1;1 (3) :225-229.