Ketotrexate (sodium)
Ketotrexate sodium is an orally active antifolate and immunosuppressant. Ketotrexate sodium has good anti-inflammatory activity and is widely used in rheumatoid arthritis (RA) . Ketotrexate sodium is used in research into cancer and autoimmune diseases[1][2].
Product Specifications
CAS Number
52386-42-2
Product Name Alternative
Emofolin (sodium) ; 5-methyltetrahydrohomofolate (sodium) ; NSC 139490 (sodium)
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ketotrexate-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(CC[C@H](NC(C1=CC=C(C=C1)NCCC2N(C3=C(NC2)NC(N)=NC3=O)C)=O)C(O[Na])=O)O[Na]
Molecular Formula
C21H25N7Na2O6
Molecular Weight
517.45
References & Citations
[1]Puig L. Methotrexate: new therapeutic approaches. Actas Dermosifiliogr. 2014 Jul-Aug;105 (6) :583-9. |[2]Torres RP, et al. Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis. ARP Rheumatol. 2022 Oct 1;1 (3) :225-229.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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