Valproic acid-d14 (sodium)
Valproic acid-d14 (sodium) is deuterium labeled Valproic acid (sodium) . Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
Product Specifications
Product Name Alternative
Sodium Valproate-d14; VPA-d14 (sodium) ; 2-Propylpentanoic acid-d14 (sodium)
UNSPSC
12352211
Hazard Statement
H302, H361
Target
Autophagy; Endogenous Metabolite; HDAC; HIV; Isotope-Labeled Compounds; Mitophagy; Notch
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
96.45
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C(C(O[Na])=O)C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
Molecular Formula
C8HD14NaO2
Molecular Weight
180.28
Precautions
H302, H361
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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