Valproic acid-d14 (sodium)

Valproic acid-d14 (sodium) is deuterium labeled Valproic acid (sodium) . Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

Product Specifications

Product Name Alternative

Sodium Valproate-d14; VPA-d14 (sodium) ; 2-Propylpentanoic acid-d14 (sodium)

UNSPSC

12352211

Hazard Statement

H302, H361

Target

Autophagy; Endogenous Metabolite; HDAC; HIV; Isotope-Labeled Compounds; Mitophagy; Notch

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

96.45

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C(C(O[Na])=O)C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]

Molecular Formula

C8HD14NaO2

Molecular Weight

180.28

Precautions

H302, H361

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85 (1) :1-10.|[3]Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31 (8) :740-50.|[4]Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30 (6) :2999-3005.|[5]Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148 (1) :31-7.|[6]Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276 (39) :36734-41.|[7]Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28.